Elizabeth Fox, MD
Elizabeth Fox, MD
Head, Developmental Therapeutics, Division of Oncology
The Children’s Hospital of Philadelphia
Improving Chemotherapy Dosing in Infants, Children, and Adolescents with Cancer
How a child’s body handles or metabolizes a drug impacts the toxic and therapeutic effects of anticancer therapy. Differences in drug disposition, sensitivity to toxic effects, and types of cancer that occur in children require that the dose of anticancer drug doses be established separately in children and adults. Studies to determine the concentration of anticancer drugs in children are necessary to determine the appropriate dose of drugs, decrease the toxicity, and improve response to therapy. This study will evaluate the pharmacokinetics of anticancer agents in children with altered physiology including infants, children or adolescents who are obese, or any child with hepatic or renal dysfunction and compare to children with normal organ function to assess dosing recommendations or dose modifications. In addition, a lecture series will be offered as a live web-based seminar to 6 pediatric oncology fellowship programs to improve the understanding and of pediatric clinical pharmacology and chemotherapy dosing and administration to children with cancer.
Mission Statement
The Strike 3 Foundation heightens awareness, mobilizes support, and raises funding for childhood cancer research.
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Strike 3 Foundation
PO Box 191
Monroe, CT 06468
(203) 724-1067